%0 Journal Article %1 Shin2020-wi %A Shin, Jean %A Ma, Shaojie %A Hofer, Edith %A Patel, Yash %A Vosberg, Daniel E %A Tilley, Steven %A Roshchupkin, Gennady V %A Sousa, André M M %A Jian, Xueqiu %A Gottesman, Rebecca %A Mosley, Thomas H %A Fornage, Myriam %A Saba, Yasaman %A Pirpamer, Lukas %A Schmidt, Reinhold %A Schmidt, Helena %A Carrion-Castillo, Amaia %A Crivello, Fabrice %A Mazoyer, Bernard %A Bis, Joshua C %A Li, Shuo %A Yang, Qiong %A Luciano, Michelle %A Karama, Sherif %A Lewis, Lindsay %A Bastin, Mark E %A Harris, Mathew A %A Wardlaw, Joanna M %A Deary, Ian E %A Scholz, Markus %A Loeffler, Markus %A Witte, A Veronica %A Beyer, Frauke %A Villringer, Arno %A Armstrong, Nicola J %A Mather, Karen A %A Ames, David %A Jiang, Jiyang %A Kwok, John B %A Schofield, Peter R %A Thalamuthu, Anbupalam %A Trollor, Julian N %A Wright, Margaret J %A Brodaty, Henry %A Wen, Wei %A Sachdev, Perminder S %A Terzikhan, Natalie %A Evans, Tavia E %A Adams, Hieab H H H %A Ikram, M Arfan %A Frenzel, Stefan %A Auwera-Palitschka, Sandra van der %A Wittfeld, Katharina %A Bülow, Robin %A Grabe, Hans Jörgen %A Tzourio, Christophe %A Mishra, Aniket %A Maingault, Sophie %A Debette, Stephanie %A Gillespie, Nathan A %A Franz, Carol E %A Kremen, William S %A Ding, Linda %A Jahanshad, Neda %A ENIGMA Consortium, %A Sestan, Nenad %A Pausova, Zdenka %A Seshadri, Sudha %A Paus, Tomas %A neuroCHARGE Working Group, %D 2020 %I Oxford University Press (OUP) %J Cereb. Cortex %K aptitude area; association brain cortical development; genome-wide occupational study; surface thickness; %N 7 %P 4121--4139 %T Global and regional development of the human cerebral cortex: Molecular architecture and occupational aptitudes %V 30 %X We have carried out meta-analyses of genome-wide association studies (GWAS) (n = 23 784) of the first two principal components (PCs) that group together cortical regions with shared variance in their surface area. PC1 (global) captured variations of most regions, whereas PC2 (visual) was specific to the primary and secondary visual cortices. We identified a total of 18 (PC1) and 17 (PC2) independent loci, which were replicated in another 25 746 individuals. The loci of the global PC1 included those associated previously with intracranial volume and/or general cognitive function, such as MAPT and IGF2BP1. The loci of the visual PC2 included DAAM1, a key player in the planar-cell-polarity pathway. We then tested associations with occupational aptitudes and, as predicted, found that the global PC1 was associated with General Learning Ability, and the visual PC2 was associated with the Form Perception aptitude. These results suggest that interindividual variations in global and regional development of the human cerebral cortex (and its molecular architecture) cascade-albeit in a very limited manner-to behaviors as complex as the choice of one's occupation.

@article{Shin2020-wi, abstract = {We have carried out meta-analyses of genome-wide association studies (GWAS) (n = 23 784) of the first two principal components (PCs) that group together cortical regions with shared variance in their surface area. PC1 (global) captured variations of most regions, whereas PC2 (visual) was specific to the primary and secondary visual cortices. We identified a total of 18 (PC1) and 17 (PC2) independent loci, which were replicated in another 25 746 individuals. The loci of the global PC1 included those associated previously with intracranial volume and/or general cognitive function, such as MAPT and IGF2BP1. The loci of the visual PC2 included DAAM1, a key player in the planar-cell-polarity pathway. We then tested associations with occupational aptitudes and, as predicted, found that the global PC1 was associated with General Learning Ability, and the visual PC2 was associated with the Form Perception aptitude. These results suggest that interindividual variations in global and regional development of the human cerebral cortex (and its molecular architecture) cascade-albeit in a very limited manner-to behaviors as complex as the choice of one's occupation.}, added-at = {2024-09-10T11:54:51.000+0200}, author = {Shin, Jean and Ma, Shaojie and Hofer, Edith and Patel, Yash and Vosberg, Daniel E and Tilley, Steven and Roshchupkin, Gennady V and Sousa, Andr{\'e} M M and Jian, Xueqiu and Gottesman, Rebecca and Mosley, Thomas H and Fornage, Myriam and Saba, Yasaman and Pirpamer, Lukas and Schmidt, Reinhold and Schmidt, Helena and Carrion-Castillo, Amaia and Crivello, Fabrice and Mazoyer, Bernard and Bis, Joshua C and Li, Shuo and Yang, Qiong and Luciano, Michelle and Karama, Sherif and Lewis, Lindsay and Bastin, Mark E and Harris, Mathew A and Wardlaw, Joanna M and Deary, Ian E and Scholz, Markus and Loeffler, Markus and Witte, A Veronica and Beyer, Frauke and Villringer, Arno and Armstrong, Nicola J and Mather, Karen A and Ames, David and Jiang, Jiyang and Kwok, John B and Schofield, Peter R and Thalamuthu, Anbupalam and Trollor, Julian N and Wright, Margaret J and Brodaty, Henry and Wen, Wei and Sachdev, Perminder S and Terzikhan, Natalie and Evans, Tavia E and Adams, Hieab H H H and Ikram, M Arfan and Frenzel, Stefan and Auwera-Palitschka, Sandra van der and Wittfeld, Katharina and B{\"u}low, Robin and Grabe, Hans J{\"o}rgen and Tzourio, Christophe and Mishra, Aniket and Maingault, Sophie and Debette, Stephanie and Gillespie, Nathan A and Franz, Carol E and Kremen, William S and Ding, Linda and Jahanshad, Neda and {ENIGMA Consortium} and Sestan, Nenad and Pausova, Zdenka and Seshadri, Sudha and Paus, Tomas and {neuroCHARGE Working Group}}, biburl = {https://puma.scadsai.uni-leipzig.de/bibtex/2ed91298f99ceb7f6c354d60c3228c4f0/scadsfct}, copyright = {https://academic.oup.com/journals/pages/open\_access/funder\_policies/chorus/standard\_publication\_model}, interhash = {a3636fb523e27cf12dce9db8502c59b3}, intrahash = {ed91298f99ceb7f6c354d60c3228c4f0}, journal = {Cereb. Cortex}, keywords = {aptitude area; association brain cortical development; genome-wide occupational study; surface thickness;}, language = {en}, month = jun, number = 7, pages = {4121--4139}, publisher = {Oxford University Press (OUP)}, timestamp = {2024-09-10T11:54:51.000+0200}, title = {Global and regional development of the human cerebral cortex: Molecular architecture and occupational aptitudes}, volume = 30, year = 2020 }