%0 Journal Article %1 Weingarten2019-lc %A Weingarten, Mark Florian Joachim %A Scholz, Markus %A Wohland, Tobias %A Horn, Katrin %A Stumvoll, Michael %A Kovacs, Peter %A Tönjes, Anke %D 2019 %I The Endocrine Society %J J. Clin. Endocrinol. Metab. %K %N 11 %P 5621--5632 %T Circulating oxytocin is genetically determined and associated with obesity and impaired glucose tolerance %V 104 %X CONTEXT: Despite the emerging evidence on the role of oxytocin (OXT) in metabolic diseases, there is a lack of well-powered studies addressing the relationship of circulating OXT with obesity and diabetes. OBJECTIVES AND DESIGN: Here, we measured OXT in a study cohort (n = 721; 396 women, 325 men; mean age $\pm$ SD, 47.7 $\pm$ 15.2 years) with subphenotypes related to obesity, including anthropometric traits such as body mass index BMI (mean $\pm$ SD), 26.8 $\pm$ 4.6 kg/m2, waist-to-hip ratio (WHR; 0.88 $\pm$ 0.09), blood parameters (glucose, 5.32 $\pm$ 0.50 mmol/L; insulin, 5.3 $\pm$ 3.3 µU/mL), and oral glucose tolerance test to clarify the association with OXT. We also tested in a genome-wide association study (GWAS) whether the interindividual variation in OXT serum levels might be explained by genetic variation. RESULTS: The OXT concentration was increased in subjects with elevated BMI and positively correlated with WHR, waist circumference, and triglyceride levels. The OXT concentration in subjects with BMI 30 kg/m2 (n = 137; 106.4 pg/mL, P = 8 $\times$ 10-6). OXT levels were also positively correlated with plasma glucose and insulin and were elevated in subjects with impaired glucose tolerance (P = 4.6 $\times$ 10-3). Heritability of OXT was estimated at 12.8\%. In a GWAS, two hits in linkage disequilibrium close (19 kb) to the OXT reached genome-wide significant association (top-hit rs12625893, P = 3.1 $\times$ 10-8, explained variance 3\%). CONCLUSIONS: Our data show that OXT is genetically affected by a variant near OXT and is associated with obesity and impaired glucose tolerance.

@article{Weingarten2019-lc, abstract = {CONTEXT: Despite the emerging evidence on the role of oxytocin (OXT) in metabolic diseases, there is a lack of well-powered studies addressing the relationship of circulating OXT with obesity and diabetes. OBJECTIVES AND DESIGN: Here, we measured OXT in a study cohort (n = 721; 396 women, 325 men; mean age $\pm$ SD, 47.7 $\pm$ 15.2 years) with subphenotypes related to obesity, including anthropometric traits such as body mass index [BMI (mean $\pm$ SD), 26.8 $\pm$ 4.6 kg/m2], waist-to-hip ratio (WHR; 0.88 $\pm$ 0.09), blood parameters (glucose, 5.32 $\pm$ 0.50 mmol/L; insulin, 5.3 $\pm$ 3.3 µU/mL), and oral glucose tolerance test to clarify the association with OXT. We also tested in a genome-wide association study (GWAS) whether the interindividual variation in OXT serum levels might be explained by genetic variation. RESULTS: The OXT concentration was increased in subjects with elevated BMI and positively correlated with WHR, waist circumference, and triglyceride levels. The OXT concentration in subjects with BMI 30 kg/m2 (n = 137; 106.4 pg/mL, P = 8 $\times$ 10-6). OXT levels were also positively correlated with plasma glucose and insulin and were elevated in subjects with impaired glucose tolerance (P = 4.6 $\times$ 10-3). Heritability of OXT was estimated at 12.8\%. In a GWAS, two hits in linkage disequilibrium close (19 kb) to the OXT reached genome-wide significant association (top-hit rs12625893, P = 3.1 $\times$ 10-8, explained variance 3\%). CONCLUSIONS: Our data show that OXT is genetically affected by a variant near OXT and is associated with obesity and impaired glucose tolerance.}, added-at = {2024-09-10T11:56:37.000+0200}, author = {Weingarten, Mark Florian Joachim and Scholz, Markus and Wohland, Tobias and Horn, Katrin and Stumvoll, Michael and Kovacs, Peter and T{\"o}njes, Anke}, biburl = {https://puma.scadsai.uni-leipzig.de/bibtex/2cf530aeb898ca9ffc2a445f2bfc0fa94/scadsfct}, interhash = {9b42f7d9d08e817b9009cce838367be6}, intrahash = {cf530aeb898ca9ffc2a445f2bfc0fa94}, journal = {J. Clin. Endocrinol. Metab.}, keywords = {}, language = {en}, month = nov, number = 11, pages = {5621--5632}, publisher = {The Endocrine Society}, timestamp = {2024-09-10T15:15:57.000+0200}, title = {Circulating oxytocin is genetically determined and associated with obesity and impaired glucose tolerance}, volume = 104, year = 2019 }