%0 Journal Article %1 Weiss2018-yd %A Weiss, Frank Ulrich %A Hesselbarth, Nico %A Párniczky, Andrea %A Mosztbacher, Dora %A Lämmerhirt, Felix %A Ruffert, Claudia %A Kovacs, Peter %A Beer, Sebastian %A Seltsam, Katharina %A Griesmann, Heidi %A Böhme, Richard %A Kaune, Tom %A Hollenbach, Marcus %A Schulz, Hans-Ulrich %A Simon, Peter %A Mayerle, Julia %A Lerch, Markus M %A Cavestro, Giulia Martina %A Zuppardo, Raffaella Alessia %A Di Leo, Milena %A Testoni, Pier Alberto %A Malecka-Panas, Ewa %A Gasirowska, Anita %A Głuszek, Stanislaw %A Bugert, Peter %A Szentesi, Andrea %A Mössner, Joachim %A Witt, Heiko %A Michl, Patrick %A Hégyi, Peter %A Scholz, Markus %A Rosendahl, Jonas %D 2018 %I Elsevier BV %J Pancreatology %K Acute Genetics; Risk Single factors; nucleotide pancreatitis; polymorphisms %N 5 %P 477--481 %T Common variants in the CLDN2-MORC4 and PRSS1-PRSS2 loci confer susceptibility to acute pancreatitis %V 18 %X BACKGROUND/OBJECTIVES: Acute pancreatitis (AP) is one of the most common gastrointestinal disorders often requiring hospitalization. Frequent aetiologies are gallstones and alcohol abuse. In contrast to chronic pancreatitis (CP) few robust genetic associations have been described. Here we analysed whether common variants in the CLDN2-MORC4 and the PRSS1-PRSS2 locus that increase recurrent AP and CP risk associate with AP. METHODS: We screened 1462 AP patients and 3999 controls with melting curve analysis for SNPs rs10273639 (PRSS1-PRSS2), rs7057398 (RIPPLY), and rs12688220 (MORC4). Calculations were performed for the overall group, aetiology, and gender sub-groups. To examine genotype-phenotype relationships we performed several meta-analyses. RESULTS: Meta-analyses of all AP patients depicted significant (p-value < 0.05) associations for rs10273639 (odds ratio (OR) 0.88, 95\% confidence interval (CI) 0.81-0.97, p-value 0.01), rs7057398 (OR 1.27, 95\% CI 1.07-1.5, p-value 0.005), and rs12688220 (OR 1.32, 95\% CI 1.12-1.56, p-value 0.001). For the different aetiology groups a significant association was shown for rs10273639 (OR 0.76, 95\% CI 0.63-0.92, p-value 0.005), rs7057398 (OR 1.43, 95\% CI 1.07-1.92, p-value 0.02), and rs12688220 (OR 1.44, 95\% CI 1.07-1.93, p-value 0.02) in the alcoholic sub-group only. CONCLUSIONS: The association of CP risk variants with different AP aetiologies, which is strongest in the alcoholic AP group, might implicate common pathomechanisms most likely between alcoholic AP and CP.

@article{Weiss2018-yd, abstract = {BACKGROUND/OBJECTIVES: Acute pancreatitis (AP) is one of the most common gastrointestinal disorders often requiring hospitalization. Frequent aetiologies are gallstones and alcohol abuse. In contrast to chronic pancreatitis (CP) few robust genetic associations have been described. Here we analysed whether common variants in the CLDN2-MORC4 and the PRSS1-PRSS2 locus that increase recurrent AP and CP risk associate with AP. METHODS: We screened 1462 AP patients and 3999 controls with melting curve analysis for SNPs rs10273639 (PRSS1-PRSS2), rs7057398 (RIPPLY), and rs12688220 (MORC4). Calculations were performed for the overall group, aetiology, and gender sub-groups. To examine genotype-phenotype relationships we performed several meta-analyses. RESULTS: Meta-analyses of all AP patients depicted significant (p-value < 0.05) associations for rs10273639 (odds ratio (OR) 0.88, 95\% confidence interval (CI) 0.81-0.97, p-value 0.01), rs7057398 (OR 1.27, 95\% CI 1.07-1.5, p-value 0.005), and rs12688220 (OR 1.32, 95\% CI 1.12-1.56, p-value 0.001). For the different aetiology groups a significant association was shown for rs10273639 (OR 0.76, 95\% CI 0.63-0.92, p-value 0.005), rs7057398 (OR 1.43, 95\% CI 1.07-1.92, p-value 0.02), and rs12688220 (OR 1.44, 95\% CI 1.07-1.93, p-value 0.02) in the alcoholic sub-group only. CONCLUSIONS: The association of CP risk variants with different AP aetiologies, which is strongest in the alcoholic AP group, might implicate common pathomechanisms most likely between alcoholic AP and CP.}, added-at = {2024-09-10T11:54:51.000+0200}, author = {Weiss, Frank Ulrich and Hesselbarth, Nico and P{\'a}rniczky, Andrea and Mosztbacher, Dora and L{\"a}mmerhirt, Felix and Ruffert, Claudia and Kovacs, Peter and Beer, Sebastian and Seltsam, Katharina and Griesmann, Heidi and B{\"o}hme, Richard and Kaune, Tom and Hollenbach, Marcus and Schulz, Hans-Ulrich and Simon, Peter and Mayerle, Julia and Lerch, Markus M and Cavestro, Giulia Martina and Zuppardo, Raffaella Alessia and Di Leo, Milena and Testoni, Pier Alberto and Malecka-Panas, Ewa and Gasirowska, Anita and G{\l}uszek, Stanislaw and Bugert, Peter and Szentesi, Andrea and M{\"o}ssner, Joachim and Witt, Heiko and Michl, Patrick and H{\'e}gyi, Peter and Scholz, Markus and Rosendahl, Jonas}, biburl = {https://puma.scadsai.uni-leipzig.de/bibtex/2e237caac02e8484bc7178a5796cc3eae/scadsfct}, interhash = {3c0ad7d5c0f5e979d940bc5a3efb8720}, intrahash = {e237caac02e8484bc7178a5796cc3eae}, journal = {Pancreatology}, keywords = {Acute Genetics; Risk Single factors; nucleotide pancreatitis; polymorphisms}, language = {en}, month = jul, number = 5, pages = {477--481}, publisher = {Elsevier BV}, timestamp = {2024-09-10T11:54:51.000+0200}, title = {Common variants in the {CLDN2-MORC4} and {PRSS1-PRSS2} loci confer susceptibility to acute pancreatitis}, volume = 18, year = 2018 }