Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample comprises 22,824 individuals from 20 cohorts within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the UK Biobank. We identify genetic heterogeneity between cortical measures and brain regions, and 160 genome-wide significant associations pointing to wnt/$\beta$-catenin, TGF-$\beta$ and sonic hedgehog pathways. There is enrichment for genes involved in anthropometric traits, hindbrain development, vascular and neurodegenerative disease and psychiatric conditions. These data are a rich resource for studies of the biological mechanisms behind cortical development and aging.
%0 Journal Article
%1 Hofer2020-aq
%A Hofer, Edith
%A Roshchupkin, Gennady V
%A Adams, Hieab H H
%A Knol, Maria J
%A Lin, Honghuang
%A Li, Shuo
%A Zare, Habil
%A Ahmad, Shahzad
%A Armstrong, Nicola J
%A Satizabal, Claudia L
%A Bernard, Manon
%A Bis, Joshua C
%A Gillespie, Nathan A
%A Luciano, Michelle
%A Mishra, Aniket
%A Scholz, Markus
%A Teumer, Alexander
%A Xia, Rui
%A Jian, Xueqiu
%A Mosley, Thomas H
%A Saba, Yasaman
%A Pirpamer, Lukas
%A Seiler, Stephan
%A Becker, James T
%A Carmichael, Owen
%A Rotter, Jerome I
%A Psaty, Bruce M
%A Lopez, Oscar L
%A Amin, Najaf
%A van der Lee, Sven J
%A Yang, Qiong
%A Himali, Jayandra J
%A Maillard, Pauline
%A Beiser, Alexa S
%A DeCarli, Charles
%A Karama, Sherif
%A Lewis, Lindsay
%A Harris, Mat
%A Bastin, Mark E
%A Deary, Ian J
%A Veronica Witte, A
%A Beyer, Frauke
%A Loeffler, Markus
%A Mather, Karen A
%A Schofield, Peter R
%A Thalamuthu, Anbupalam
%A Kwok, John B
%A Wright, Margaret J
%A Ames, David
%A Trollor, Julian
%A Jiang, Jiyang
%A Brodaty, Henry
%A Wen, Wei
%A Vernooij, Meike W
%A Hofman, Albert
%A Uitterlinden, André G
%A Niessen, Wiro J
%A Wittfeld, Katharina
%A Bülow, Robin
%A Völker, Uwe
%A Pausova, Zdenka
%A Bruce Pike, G
%A Maingault, Sophie
%A Crivello, Fabrice
%A Tzourio, Christophe
%A Amouyel, Philippe
%A Mazoyer, Bernard
%A Neale, Michael C
%A Franz, Carol E
%A Lyons, Michael J
%A Panizzon, Matthew S
%A Andreassen, Ole A
%A Dale, Anders M
%A Logue, Mark
%A Grasby, Katrina L
%A Jahanshad, Neda
%A Painter, Jodie N
%A Colodro-Conde, Luc\'ıa
%A Bralten, Janita
%A Hibar, Derrek P
%A Lind, Penelope A
%A Pizzagalli, Fabrizio
%A Stein, Jason L
%A Thompson, Paul M
%A Medland, Sarah E
%A ENIGMA consortium,
%A Sachdev, Perminder S
%A Kremen, William S
%A Wardlaw, Joanna M
%A Villringer, Arno
%A van Duijn, Cornelia M
%A Grabe, Hans J
%A Longstreth, Jr, William T
%A Fornage, Myriam
%A Paus, Tomas
%A Debette, Stephanie
%A Ikram, M Arfan
%A Schmidt, Helena
%A Schmidt, Reinhold
%A Seshadri, Sudha
%D 2020
%I Springer Science and Business Media LLC
%J Nat. Commun.
%K topic_lifescience
%N 1
%P 4796
%T Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults
%V 11
%X Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample comprises 22,824 individuals from 20 cohorts within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the UK Biobank. We identify genetic heterogeneity between cortical measures and brain regions, and 160 genome-wide significant associations pointing to wnt/$\beta$-catenin, TGF-$\beta$ and sonic hedgehog pathways. There is enrichment for genes involved in anthropometric traits, hindbrain development, vascular and neurodegenerative disease and psychiatric conditions. These data are a rich resource for studies of the biological mechanisms behind cortical development and aging.
@article{Hofer2020-aq,
abstract = {Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample comprises 22,824 individuals from 20 cohorts within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the UK Biobank. We identify genetic heterogeneity between cortical measures and brain regions, and 160 genome-wide significant associations pointing to wnt/$\beta$-catenin, TGF-$\beta$ and sonic hedgehog pathways. There is enrichment for genes involved in anthropometric traits, hindbrain development, vascular and neurodegenerative disease and psychiatric conditions. These data are a rich resource for studies of the biological mechanisms behind cortical development and aging.},
added-at = {2024-09-10T11:56:37.000+0200},
author = {Hofer, Edith and Roshchupkin, Gennady V and Adams, Hieab H H and Knol, Maria J and Lin, Honghuang and Li, Shuo and Zare, Habil and Ahmad, Shahzad and Armstrong, Nicola J and Satizabal, Claudia L and Bernard, Manon and Bis, Joshua C and Gillespie, Nathan A and Luciano, Michelle and Mishra, Aniket and Scholz, Markus and Teumer, Alexander and Xia, Rui and Jian, Xueqiu and Mosley, Thomas H and Saba, Yasaman and Pirpamer, Lukas and Seiler, Stephan and Becker, James T and Carmichael, Owen and Rotter, Jerome I and Psaty, Bruce M and Lopez, Oscar L and Amin, Najaf and van der Lee, Sven J and Yang, Qiong and Himali, Jayandra J and Maillard, Pauline and Beiser, Alexa S and DeCarli, Charles and Karama, Sherif and Lewis, Lindsay and Harris, Mat and Bastin, Mark E and Deary, Ian J and Veronica Witte, A and Beyer, Frauke and Loeffler, Markus and Mather, Karen A and Schofield, Peter R and Thalamuthu, Anbupalam and Kwok, John B and Wright, Margaret J and Ames, David and Trollor, Julian and Jiang, Jiyang and Brodaty, Henry and Wen, Wei and Vernooij, Meike W and Hofman, Albert and Uitterlinden, Andr{\'e} G and Niessen, Wiro J and Wittfeld, Katharina and B{\"u}low, Robin and V{\"o}lker, Uwe and Pausova, Zdenka and Bruce Pike, G and Maingault, Sophie and Crivello, Fabrice and Tzourio, Christophe and Amouyel, Philippe and Mazoyer, Bernard and Neale, Michael C and Franz, Carol E and Lyons, Michael J and Panizzon, Matthew S and Andreassen, Ole A and Dale, Anders M and Logue, Mark and Grasby, Katrina L and Jahanshad, Neda and Painter, Jodie N and Colodro-Conde, Luc{\'\i}a and Bralten, Janita and Hibar, Derrek P and Lind, Penelope A and Pizzagalli, Fabrizio and Stein, Jason L and Thompson, Paul M and Medland, Sarah E and {ENIGMA consortium} and Sachdev, Perminder S and Kremen, William S and Wardlaw, Joanna M and Villringer, Arno and van Duijn, Cornelia M and Grabe, Hans J and {Longstreth, Jr}, William T and Fornage, Myriam and Paus, Tomas and Debette, Stephanie and Ikram, M Arfan and Schmidt, Helena and Schmidt, Reinhold and Seshadri, Sudha},
biburl = {https://puma.scadsai.uni-leipzig.de/bibtex/2dd9f020d2daf077029736ed8333a3254/scadsfct},
copyright = {https://creativecommons.org/licenses/by/4.0},
interhash = {25791b8c0b73532f65b1d4f1890af35f},
intrahash = {dd9f020d2daf077029736ed8333a3254},
journal = {Nat. Commun.},
keywords = {topic_lifescience},
language = {en},
month = sep,
number = 1,
pages = 4796,
publisher = {Springer Science and Business Media LLC},
timestamp = {2024-09-10T14:02:01.000+0200},
title = {Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults},
volume = 11,
year = 2020
}
