AbstractThe volume of the lateral ventricles (LV) increases with age and their abnormal enlargement is a key feature of several neurological and psychiatric diseases. Although lateral ventricular volume is heritable, a comprehensive investigation of its genetic determinants is lacking. In this meta-analysis of genome-wide association studies of 23,533 healthy middle-aged to elderly individuals from 26 population-based cohorts, we identify 7 genetic loci associated with LV volume. These loci map to chromosomes 3q28, 7p22.3, 10p12.31, 11q23.1, 12q23.3, 16q24.2, and 22q13.1 and implicate pathways related to tau pathology, S1P signaling, and cytoskeleton organization. We also report a significant genetic overlap between the thalamus and LV volumes ($\rho$genetic = −0.59, p-value = 3.14 $\times$ 10−6), suggesting that these brain structures may share a common biology. These genetic associations of LV volume provide insights into brain morphology.
%0 Journal Article
%1 Vojinovic2018-ao
%A Vojinovic, Dina
%A Adams, Hieab H
%A Jian, Xueqiu
%A Yang, Qiong
%A Smith, Albert Vernon
%A Bis, Joshua C
%A Teumer, Alexander
%A Scholz, Markus
%A Armstrong, Nicola J
%A Hofer, Edith
%A Saba, Yasaman
%A Luciano, Michelle
%A Bernard, Manon
%A Trompet, Stella
%A Yang, Jingyun
%A Gillespie, Nathan A
%A van der Lee, Sven J
%A Neumann, Alexander
%A Ahmad, Shahzad
%A Andreassen, Ole A
%A Ames, David
%A Amin, Najaf
%A Arfanakis, Konstantinos
%A Bastin, Mark E
%A Becker, Diane M
%A Beiser, Alexa S
%A Beyer, Frauke
%A Brodaty, Henry
%A Bryan, R Nick
%A Bülow, Robin
%A Dale, Anders M
%A De Jager, Philip L
%A Deary, Ian J
%A DeCarli, Charles
%A Fleischman, Debra A
%A Gottesman, Rebecca F
%A van der Grond, Jeroen
%A Gudnason, Vilmundur
%A Harris, Tamara B
%A Homuth, Georg
%A Knopman, David S
%A Kwok, John B
%A Lewis, Cora E
%A Li, Shuo
%A Loeffler, Markus
%A Lopez, Oscar L
%A Maillard, Pauline
%A El Marroun, Hanan
%A Mather, Karen A
%A Mosley, Thomas H
%A Muetzel, Ryan L
%A Nauck, Matthias
%A Nyquist, Paul A
%A Panizzon, Matthew S
%A Pausova, Zdenka
%A Psaty, Bruce M
%A Rice, Ken
%A Rotter, Jerome I
%A Royle, Natalie
%A Satizabal, Claudia L
%A Schmidt, Reinhold
%A Schofield, Peter R
%A Schreiner, Pamela J
%A Sidney, Stephen
%A Stott, David J
%A Thalamuthu, Anbupalam
%A Uitterlinden, Andre G
%A Valdés Hernández, Maria C
%A Vernooij, Meike W
%A Wen, Wei
%A White, Tonya
%A Witte, A Veronica
%A Wittfeld, Katharina
%A Wright, Margaret J
%A Yanek, Lisa R
%A Tiemeier, Henning
%A Kremen, William S
%A Bennett, David A
%A Jukema, J Wouter
%A Paus, Tomas
%A Wardlaw, Joanna M
%A Schmidt, Helena
%A Sachdev, Perminder S
%A Villringer, Arno
%A Grabe, Hans Jörgen
%A Longstreth, W T
%A van Duijn, Cornelia M
%A Launer, Lenore J
%A Seshadri, Sudha
%A Ikram, M Arfan
%A Fornage, Myriam
%D 2018
%I Springer Science and Business Media LLC
%J Nat. Commun.
%K topic_lifescience
%N 1
%P 3945
%T Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume
%V 9
%X AbstractThe volume of the lateral ventricles (LV) increases with age and their abnormal enlargement is a key feature of several neurological and psychiatric diseases. Although lateral ventricular volume is heritable, a comprehensive investigation of its genetic determinants is lacking. In this meta-analysis of genome-wide association studies of 23,533 healthy middle-aged to elderly individuals from 26 population-based cohorts, we identify 7 genetic loci associated with LV volume. These loci map to chromosomes 3q28, 7p22.3, 10p12.31, 11q23.1, 12q23.3, 16q24.2, and 22q13.1 and implicate pathways related to tau pathology, S1P signaling, and cytoskeleton organization. We also report a significant genetic overlap between the thalamus and LV volumes ($\rho$genetic = −0.59, p-value = 3.14 $\times$ 10−6), suggesting that these brain structures may share a common biology. These genetic associations of LV volume provide insights into brain morphology.
@article{Vojinovic2018-ao,
abstract = {AbstractThe volume of the lateral ventricles (LV) increases with age and their abnormal enlargement is a key feature of several neurological and psychiatric diseases. Although lateral ventricular volume is heritable, a comprehensive investigation of its genetic determinants is lacking. In this meta-analysis of genome-wide association studies of 23,533 healthy middle-aged to elderly individuals from 26 population-based cohorts, we identify 7 genetic loci associated with LV volume. These loci map to chromosomes 3q28, 7p22.3, 10p12.31, 11q23.1, 12q23.3, 16q24.2, and 22q13.1 and implicate pathways related to tau pathology, S1P signaling, and cytoskeleton organization. We also report a significant genetic overlap between the thalamus and LV volumes ($\rho$genetic = −0.59, p-value = 3.14 $\times$ 10−6), suggesting that these brain structures may share a common biology. These genetic associations of LV volume provide insights into brain morphology.},
added-at = {2024-09-10T11:56:37.000+0200},
author = {Vojinovic, Dina and Adams, Hieab H and Jian, Xueqiu and Yang, Qiong and Smith, Albert Vernon and Bis, Joshua C and Teumer, Alexander and Scholz, Markus and Armstrong, Nicola J and Hofer, Edith and Saba, Yasaman and Luciano, Michelle and Bernard, Manon and Trompet, Stella and Yang, Jingyun and Gillespie, Nathan A and van der Lee, Sven J and Neumann, Alexander and Ahmad, Shahzad and Andreassen, Ole A and Ames, David and Amin, Najaf and Arfanakis, Konstantinos and Bastin, Mark E and Becker, Diane M and Beiser, Alexa S and Beyer, Frauke and Brodaty, Henry and Bryan, R Nick and B{\"u}low, Robin and Dale, Anders M and De Jager, Philip L and Deary, Ian J and DeCarli, Charles and Fleischman, Debra A and Gottesman, Rebecca F and van der Grond, Jeroen and Gudnason, Vilmundur and Harris, Tamara B and Homuth, Georg and Knopman, David S and Kwok, John B and Lewis, Cora E and Li, Shuo and Loeffler, Markus and Lopez, Oscar L and Maillard, Pauline and El Marroun, Hanan and Mather, Karen A and Mosley, Thomas H and Muetzel, Ryan L and Nauck, Matthias and Nyquist, Paul A and Panizzon, Matthew S and Pausova, Zdenka and Psaty, Bruce M and Rice, Ken and Rotter, Jerome I and Royle, Natalie and Satizabal, Claudia L and Schmidt, Reinhold and Schofield, Peter R and Schreiner, Pamela J and Sidney, Stephen and Stott, David J and Thalamuthu, Anbupalam and Uitterlinden, Andre G and Vald{\'e}s Hern{\'a}ndez, Maria C and Vernooij, Meike W and Wen, Wei and White, Tonya and Witte, A Veronica and Wittfeld, Katharina and Wright, Margaret J and Yanek, Lisa R and Tiemeier, Henning and Kremen, William S and Bennett, David A and Jukema, J Wouter and Paus, Tomas and Wardlaw, Joanna M and Schmidt, Helena and Sachdev, Perminder S and Villringer, Arno and Grabe, Hans J{\"o}rgen and Longstreth, W T and van Duijn, Cornelia M and Launer, Lenore J and Seshadri, Sudha and Ikram, M Arfan and Fornage, Myriam},
biburl = {https://puma.scadsai.uni-leipzig.de/bibtex/2b629608fb134d7689c3134083a6b84b9/scadsfct},
copyright = {https://creativecommons.org/licenses/by/4.0},
interhash = {bb5808f114e1b87211ddabf4e044aa28},
intrahash = {b629608fb134d7689c3134083a6b84b9},
journal = {Nat. Commun.},
keywords = {topic_lifescience},
language = {en},
month = sep,
number = 1,
pages = 3945,
publisher = {Springer Science and Business Media LLC},
timestamp = {2024-09-10T14:02:01.000+0200},
title = {Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume},
volume = 9,
year = 2018
}
