%0 Journal Article %1 Grobner2018-en %A Gröbner, Susanne N %A ICGC PedBrain-Seq Project, %A Worst, Barbara C %A Weischenfeldt, Joachim %A Buchhalter, Ivo %A Kleinheinz, Kortine %A Rudneva, Vasilisa A %A Johann, Pascal D %A Balasubramanian, Gnana Prakash %A Segura-Wang, Maia %A Brabetz, Sebastian %A Bender, Sebastian %A Hutter, Barbara %A Sturm, Dominik %A Pfaff, Elke %A Hübschmann, Daniel %A Zipprich, Gideon %A Heinold, Michael %A Eils, Jürgen %A Lawerenz, Christian %A Erkek, Serap %A Lambo, Sander %A Waszak, Sebastian %A Blattmann, Claudia %A Borkhardt, Arndt %A Kuhlen, Michaela %A Eggert, Angelika %A Fulda, Simone %A Gessler, Manfred %A Wegert, Jenny %A Kappler, Roland %A Baumhoer, Daniel %A Burdach, Stefan %A Kirschner-Schwabe, Renate %A Kontny, Udo %A Kulozik, Andreas E %A Lohmann, Dietmar %A Hettmer, Simone %A Eckert, Cornelia %A Bielack, Stefan %A Nathrath, Michaela %A Niemeyer, Charlotte %A Richter, Günther H %A Schulte, Johannes %A Siebert, Reiner %A Westermann, Frank %A Molenaar, Jan J %A Vassal, Gilles %A Witt, Hendrik %A Burkhardt, Birgit %A Kratz, Christian P %A Witt, Olaf %A van Tilburg, Cornelis M %A Kramm, Christof M %A Fleischhack, Gudrun %A Dirksen, Uta %A Rutkowski, Stefan %A Frühwald, Michael %A von Hoff, Katja %A Wolf, Stephan %A Klingebiel, Thomas %A Koscielniak, Ewa %A Landgraf, Pablo %A Koster, Jan %A Resnick, Adam C %A Zhang, Jinghui %A Liu, Yanling %A Zhou, Xin %A Waanders, Angela J %A Zwijnenburg, Danny A %A Raman, Pichai %A Brors, Benedikt %A Weber, Ursula D %A Northcott, Paul A %A Pajtler, Kristian W %A Kool, Marcel %A Piro, Rosario M %A Korbel, Jan O %A Schlesner, Matthias %A Eils, Roland %A Jones, David T W %A Lichter, Peter %A Chavez, Lukas %A Zapatka, Marc %A Pfister, Stefan M %A ICGC MMML-Seq Project, %D 2018 %I Springer Science and Business Media LLC %J Nature %K topic_lifescience %N 7696 %P 321--327 %T The landscape of genomic alterations across childhood cancers %V 555 %X Abstract Pan-cancer analyses that examine commonalities and differences among various cancer types have emerged as a powerful way to obtain novel insights into cancer biology. Here we present a comprehensive analysis of genetic alterations in a pan-cancer cohort including 961 tumours from children, adolescents, and young adults, comprising 24 distinct molecular types of cancer. Using a standardized workflow, we identified marked differences in terms of mutation frequency and significantly mutated genes in comparison to previously analysed adult cancers. Genetic alterations in 149 putative cancer driver genes separate the tumours into two classes: small mutation and structural/copy-number variant (correlating with germline variants). Structural variants, hyperdiploidy, and chromothripsis are linked to TP53 mutation status and mutational signatures. Our data suggest that 7--8\% of the children in this cohort carry an unambiguous predisposing germline variant and that nearly 50\% of paediatric neoplasms harbour a potentially druggable event, which is highly relevant for the design of future clinical trials.

@article{Grobner2018-en, abstract = {Abstract Pan-cancer analyses that examine commonalities and differences among various cancer types have emerged as a powerful way to obtain novel insights into cancer biology. Here we present a comprehensive analysis of genetic alterations in a pan-cancer cohort including 961 tumours from children, adolescents, and young adults, comprising 24 distinct molecular types of cancer. Using a standardized workflow, we identified marked differences in terms of mutation frequency and significantly mutated genes in comparison to previously analysed adult cancers. Genetic alterations in 149 putative cancer driver genes separate the tumours into two classes: small mutation and structural/copy-number variant (correlating with germline variants). Structural variants, hyperdiploidy, and chromothripsis are linked to TP53 mutation status and mutational signatures. Our data suggest that 7--8\% of the children in this cohort carry an unambiguous predisposing germline variant and that nearly 50\% of paediatric neoplasms harbour a potentially druggable event, which is highly relevant for the design of future clinical trials.}, added-at = {2024-09-10T11:56:37.000+0200}, author = {Gr{\"o}bner, Susanne N and {ICGC PedBrain-Seq Project} and Worst, Barbara C and Weischenfeldt, Joachim and Buchhalter, Ivo and Kleinheinz, Kortine and Rudneva, Vasilisa A and Johann, Pascal D and Balasubramanian, Gnana Prakash and Segura-Wang, Maia and Brabetz, Sebastian and Bender, Sebastian and Hutter, Barbara and Sturm, Dominik and Pfaff, Elke and H{\"u}bschmann, Daniel and Zipprich, Gideon and Heinold, Michael and Eils, J{\"u}rgen and Lawerenz, Christian and Erkek, Serap and Lambo, Sander and Waszak, Sebastian and Blattmann, Claudia and Borkhardt, Arndt and Kuhlen, Michaela and Eggert, Angelika and Fulda, Simone and Gessler, Manfred and Wegert, Jenny and Kappler, Roland and Baumhoer, Daniel and Burdach, Stefan and Kirschner-Schwabe, Renate and Kontny, Udo and Kulozik, Andreas E and Lohmann, Dietmar and Hettmer, Simone and Eckert, Cornelia and Bielack, Stefan and Nathrath, Michaela and Niemeyer, Charlotte and Richter, G{\"u}nther H and Schulte, Johannes and Siebert, Reiner and Westermann, Frank and Molenaar, Jan J and Vassal, Gilles and Witt, Hendrik and Burkhardt, Birgit and Kratz, Christian P and Witt, Olaf and van Tilburg, Cornelis M and Kramm, Christof M and Fleischhack, Gudrun and Dirksen, Uta and Rutkowski, Stefan and Fr{\"u}hwald, Michael and von Hoff, Katja and Wolf, Stephan and Klingebiel, Thomas and Koscielniak, Ewa and Landgraf, Pablo and Koster, Jan and Resnick, Adam C and Zhang, Jinghui and Liu, Yanling and Zhou, Xin and Waanders, Angela J and Zwijnenburg, Danny A and Raman, Pichai and Brors, Benedikt and Weber, Ursula D and Northcott, Paul A and Pajtler, Kristian W and Kool, Marcel and Piro, Rosario M and Korbel, Jan O and Schlesner, Matthias and Eils, Roland and Jones, David T W and Lichter, Peter and Chavez, Lukas and Zapatka, Marc and Pfister, Stefan M and {ICGC MMML-Seq Project}}, biburl = {https://puma.scadsai.uni-leipzig.de/bibtex/29ad15707b7f3c777f7b1d3532fc0570a/scadsfct}, copyright = {https://creativecommons.org/licenses/by/4.0}, interhash = {c3766330b776be14769f05e78adaf075}, intrahash = {9ad15707b7f3c777f7b1d3532fc0570a}, journal = {Nature}, keywords = {topic_lifescience}, language = {en}, month = mar, number = 7696, pages = {321--327}, publisher = {Springer Science and Business Media LLC}, timestamp = {2024-09-10T14:02:01.000+0200}, title = {The landscape of genomic alterations across childhood cancers}, volume = 555, year = 2018 }