The placenta remains the key organ to pregnancy complications, such as preeclampsia, contrarily the pathophysiology underlying the placental dysfunctions remains elusive. Here, we present our Disease Map ``NaviCenta'', which is an online resource based on the interactions between tissues, cellular compartments, and molecules that mediate disease-related processes in the placenta. We built cellular and molecular interaction networks based upon manual curation and annotation of publicly available information in the scientific literature, pathways resources, and Omics data. NaviCenta (Navigate the plaCenta) serves as an open access, spatio-temporal, multi-scale knowledge base, and analytical tool for enhanced interpretation and hypothesis testing on various placental disease phenotypes.
%0 Journal Article
%1 Scheel2023-zb
%A Scheel, Julia
%A Hoch, Matti
%A Wolfien, Markus
%A Gupta, Shailendra
%D 2023
%I Elsevier BV
%J Placenta
%K Molecular Networks Omics Systems analysis; biology integration; interaction map;
%P 12--15
%T NaviCenta - The disease map for placental research
%V 143
%X The placenta remains the key organ to pregnancy complications, such as preeclampsia, contrarily the pathophysiology underlying the placental dysfunctions remains elusive. Here, we present our Disease Map ``NaviCenta'', which is an online resource based on the interactions between tissues, cellular compartments, and molecules that mediate disease-related processes in the placenta. We built cellular and molecular interaction networks based upon manual curation and annotation of publicly available information in the scientific literature, pathways resources, and Omics data. NaviCenta (Navigate the plaCenta) serves as an open access, spatio-temporal, multi-scale knowledge base, and analytical tool for enhanced interpretation and hypothesis testing on various placental disease phenotypes.
@article{Scheel2023-zb,
abstract = {The placenta remains the key organ to pregnancy complications, such as preeclampsia, contrarily the pathophysiology underlying the placental dysfunctions remains elusive. Here, we present our Disease Map ``NaviCenta'', which is an online resource based on the interactions between tissues, cellular compartments, and molecules that mediate disease-related processes in the placenta. We built cellular and molecular interaction networks based upon manual curation and annotation of publicly available information in the scientific literature, pathways resources, and Omics data. NaviCenta (Navigate the plaCenta) serves as an open access, spatio-temporal, multi-scale knowledge base, and analytical tool for enhanced interpretation and hypothesis testing on various placental disease phenotypes.},
added-at = {2024-09-10T10:41:24.000+0200},
author = {Scheel, Julia and Hoch, Matti and Wolfien, Markus and Gupta, Shailendra},
biburl = {https://puma.scadsai.uni-leipzig.de/bibtex/28c937ad991b0bd94c83b597eb08e6d68/scadsfct},
copyright = {http://creativecommons.org/licenses/by-nc/4.0/},
interhash = {20c933260e3832d4dda18637d94f6b86},
intrahash = {8c937ad991b0bd94c83b597eb08e6d68},
journal = {Placenta},
keywords = {Molecular Networks Omics Systems analysis; biology integration; interaction map;},
language = {en},
month = nov,
pages = {12--15},
publisher = {Elsevier BV},
timestamp = {2024-09-10T10:45:25.000+0200},
title = {{NaviCenta} - The disease map for placental research},
volume = 143,
year = 2023
}
