%0 Journal Article %1 Vogelezang2020-id %A Vogelezang, Suzanne %A Bradfield, Jonathan P %A Ahluwalia, Tarunveer S %A Curtin, John A %A Lakka, Timo A %A Grarup, Niels %A Scholz, Markus %A van der Most, Peter J %A Monnereau, Claire %A Stergiakouli, Evie %A Heiskala, Anni %A Horikoshi, Momoko %A Fedko, Iryna O %A Vilor-Tejedor, Natalia %A Cousminer, Diana L %A Standl, Marie %A Wang, Carol A %A Viikari, Jorma %A Geller, Frank %A Íñiguez, Carmen %A Pitkänen, Niina %A Chesi, Alessandra %A Bacelis, Jonas %A Yengo, Loic %A Torrent, Maties %A Ntalla, Ioanna %A Helgeland, Øyvind %A Selzam, Saskia %A Vonk, Judith M %A Zafarmand, Mohammed H %A Heude, Barbara %A Farooqi, Ismaa Sadaf %A Alyass, Akram %A Beaumont, Robin N %A Have, Christian T %A Rzehak, Peter %A Bilbao, Jose Ramon %A Schnurr, Theresia M %A Barroso, Inês %A Bønnelykke, Klaus %A Beilin, Lawrence J %A Carstensen, Lisbeth %A Charles, Marie-Aline %A Chawes, Bo %A Clément, Karine %A Closa-Monasterolo, Ricardo %A Custovic, Adnan %A Eriksson, Johan G %A Escribano, Joaquin %A Groen-Blokhuis, Maria %A Grote, Veit %A Gruszfeld, Dariusz %A Hakonarson, Hakon %A Hansen, Torben %A Hattersley, Andrew T %A Hollensted, Mette %A Hottenga, Jouke-Jan %A Hyppönen, Elina %A Johansson, Stefan %A Joro, Raimo %A Kähönen, Mika %A Karhunen, Ville %A Kiess, Wieland %A Knight, Bridget A %A Koletzko, Berthold %A Kühnapfel, Andreas %A Landgraf, Kathrin %A Langhendries, Jean-Paul %A Lehtimäki, Terho %A Leinonen, Jaakko T %A Li, Aihuali %A Lindi, Virpi %A Lowry, Estelle %A Bustamante, Mariona %A Medina-Gomez, Carolina %A Melbye, Mads %A Michaelsen, Kim F %A Morgen, Camilla S %A Mori, Trevor A %A Nielsen, Tenna R H %A Niinikoski, Harri %A Oldehinkel, Albertine J %A Pahkala, Katja %A Panoutsopoulou, Kalliope %A Pedersen, Oluf %A Pennell, Craig E %A Power, Christine %A Reijneveld, Sijmen A %A Rivadeneira, Fernando %A Simpson, Angela %A Sly, Peter D %A Stokholm, Jakob %A Teo, Kook K %A Thiering, Elisabeth %A Timpson, Nicholas J %A Uitterlinden, André G %A van Beijsterveldt, Catharina E M %A van Schaik, Barbera D C %A Vaudel, Marc %A Verduci, Elvira %A Vinding, Rebecca K %A Vogel, Mandy %A Zeggini, Eleftheria %A Sebert, Sylvain %A Lind, Mads V %A Brown, Christopher D %A Santa-Marina, Loreto %A Reischl, Eva %A Frithioff-Bøjsœ, Christine %A Meyre, David %A Wheeler, Eleanor %A Ong, Ken %A Nohr, Ellen A %A Vrijkotte, Tanja G M %A Koppelman, Gerard H %A Plomin, Robert %A Njølstad, P\aal R %A Dedoussis, George D %A Froguel, Philippe %A Sørensen, Thorkild I A %A Jacobsson, Bo %A Freathy, Rachel M %A Zemel, Babette S %A Raitakari, Olli %A Vrijheid, Martine %A Feenstra, Bjarke %A Lyytikäinen, Leo-Pekka %A Snieder, Harold %A Kirsten, Holger %A Holt, Patrick G %A Heinrich, Joachim %A Widén, Elisabeth %A Sunyer, Jordi %A Boomsma, Dorret I %A Järvelin, Marjo-Riitta %A Körner, Antje %A Davey Smith, George %A Holm, Jens-Christian %A Atalay, Mustafa %A Murray, Clare %A Bisgaard, Hans %A McCarthy, Mark I %A Early Growth Genetics Consortium, %A Jaddoe, Vincent W V %A Grant, Struan F A %A Felix, Janine F %D 2020 %I Public Library of Science (PLoS) %J PLoS Genet. %K topic_lifescience %N 10 %P e1008718 %T Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits %V 16 %X The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located near NEDD4L and SLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 diabetes were detected (Rg ranging from 0.11 to 0.76, P-values <0.002). A negative genetic correlation of childhood BMI with age at menarche was observed. Our results suggest that the biological processes underlying childhood BMI largely, but not completely, overlap with those underlying adult BMI. The well-known observational associations of BMI in childhood with cardio-metabolic diseases in adulthood may reflect partial genetic overlap, but in light of previous evidence, it is also likely that they are explained through phenotypic continuity of BMI from childhood into adulthood.

@article{Vogelezang2020-id, abstract = {The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located near NEDD4L and SLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 diabetes were detected (Rg ranging from 0.11 to 0.76, P-values <0.002). A negative genetic correlation of childhood BMI with age at menarche was observed. Our results suggest that the biological processes underlying childhood BMI largely, but not completely, overlap with those underlying adult BMI. The well-known observational associations of BMI in childhood with cardio-metabolic diseases in adulthood may reflect partial genetic overlap, but in light of previous evidence, it is also likely that they are explained through phenotypic continuity of BMI from childhood into adulthood.}, added-at = {2024-09-10T11:56:37.000+0200}, author = {Vogelezang, Suzanne and Bradfield, Jonathan P and Ahluwalia, Tarunveer S and Curtin, John A and Lakka, Timo A and Grarup, Niels and Scholz, Markus and van der Most, Peter J and Monnereau, Claire and Stergiakouli, Evie and Heiskala, Anni and Horikoshi, Momoko and Fedko, Iryna O and Vilor-Tejedor, Natalia and Cousminer, Diana L and Standl, Marie and Wang, Carol A and Viikari, Jorma and Geller, Frank and {\'I}{\~n}iguez, Carmen and Pitk{\"a}nen, Niina and Chesi, Alessandra and Bacelis, Jonas and Yengo, Loic and Torrent, Maties and Ntalla, Ioanna and Helgeland, {\O}yvind and Selzam, Saskia and Vonk, Judith M and Zafarmand, Mohammed H and Heude, Barbara and Farooqi, Ismaa Sadaf and Alyass, Akram and Beaumont, Robin N and Have, Christian T and Rzehak, Peter and Bilbao, Jose Ramon and Schnurr, Theresia M and Barroso, In{\^e}s and B{\o}nnelykke, Klaus and Beilin, Lawrence J and Carstensen, Lisbeth and Charles, Marie-Aline and Chawes, Bo and Cl{\'e}ment, Karine and Closa-Monasterolo, Ricardo and Custovic, Adnan and Eriksson, Johan G and Escribano, Joaquin and Groen-Blokhuis, Maria and Grote, Veit and Gruszfeld, Dariusz and Hakonarson, Hakon and Hansen, Torben and Hattersley, Andrew T and Hollensted, Mette and Hottenga, Jouke-Jan and Hypp{\"o}nen, Elina and Johansson, Stefan and Joro, Raimo and K{\"a}h{\"o}nen, Mika and Karhunen, Ville and Kiess, Wieland and Knight, Bridget A and Koletzko, Berthold and K{\"u}hnapfel, Andreas and Landgraf, Kathrin and Langhendries, Jean-Paul and Lehtim{\"a}ki, Terho and Leinonen, Jaakko T and Li, Aihuali and Lindi, Virpi and Lowry, Estelle and Bustamante, Mariona and Medina-Gomez, Carolina and Melbye, Mads and Michaelsen, Kim F and Morgen, Camilla S and Mori, Trevor A and Nielsen, Tenna R H and Niinikoski, Harri and Oldehinkel, Albertine J and Pahkala, Katja and Panoutsopoulou, Kalliope and Pedersen, Oluf and Pennell, Craig E and Power, Christine and Reijneveld, Sijmen A and Rivadeneira, Fernando and Simpson, Angela and Sly, Peter D and Stokholm, Jakob and Teo, Kook K and Thiering, Elisabeth and Timpson, Nicholas J and Uitterlinden, Andr{\'e} G and van Beijsterveldt, Catharina E M and van Schaik, Barbera D C and Vaudel, Marc and Verduci, Elvira and Vinding, Rebecca K and Vogel, Mandy and Zeggini, Eleftheria and Sebert, Sylvain and Lind, Mads V and Brown, Christopher D and Santa-Marina, Loreto and Reischl, Eva and Frithioff-B{\o}js{\o}e, Christine and Meyre, David and Wheeler, Eleanor and Ong, Ken and Nohr, Ellen A and Vrijkotte, Tanja G M and Koppelman, Gerard H and Plomin, Robert and Nj{\o}lstad, P{\aa}l R and Dedoussis, George D and Froguel, Philippe and S{\o}rensen, Thorkild I A and Jacobsson, Bo and Freathy, Rachel M and Zemel, Babette S and Raitakari, Olli and Vrijheid, Martine and Feenstra, Bjarke and Lyytik{\"a}inen, Leo-Pekka and Snieder, Harold and Kirsten, Holger and Holt, Patrick G and Heinrich, Joachim and Wid{\'e}n, Elisabeth and Sunyer, Jordi and Boomsma, Dorret I and J{\"a}rvelin, Marjo-Riitta and K{\"o}rner, Antje and Davey Smith, George and Holm, Jens-Christian and Atalay, Mustafa and Murray, Clare and Bisgaard, Hans and McCarthy, Mark I and {Early Growth Genetics Consortium} and Jaddoe, Vincent W V and Grant, Struan F A and Felix, Janine F}, biburl = {https://puma.scadsai.uni-leipzig.de/bibtex/229139fcd5468a4b1a4447268178cdbcd/scadsfct}, copyright = {http://creativecommons.org/licenses/by/4.0/}, interhash = {267574160806c0f780b5e03085a580e2}, intrahash = {29139fcd5468a4b1a4447268178cdbcd}, journal = {PLoS Genet.}, keywords = {topic_lifescience}, language = {en}, month = oct, number = 10, pages = {e1008718}, publisher = {Public Library of Science (PLoS)}, timestamp = {2024-09-10T13:58:29.000+0200}, title = {Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits}, volume = 16, year = 2020 }