Rad52 is a highly conserved eukaryotic protein that can mediate the annealing of complementary DNA strands to initiate homologous recombination for the repair of double-strand breaks. Suspicions that at least some prokaryotic single-strand annealing proteins (SSAPs) are related to Rad52 have been discussed for more than two decades. Two recent cryo-EM structures, now put the issue beyond doubt.
%0 Journal Article
%1 901e3f89aab84244a9b9c1a17b6efd57
%A Al-Fatlawi, Ali
%A Schroeder, Michael
%A Stewart, A Francis
%D 2023
%I Springer Nature
%J Communications biology
%K topic_lifescience DNA FIS_scads Homologous Protein/genetics Rad52 Recombination Recombination, Repair and
%N 1
%R 10.1038/s42003-023-04476-z
%T The Rad52 SSAP superfamily and new insight into homologous recombination
%V 6
%X Rad52 is a highly conserved eukaryotic protein that can mediate the annealing of complementary DNA strands to initiate homologous recombination for the repair of double-strand breaks. Suspicions that at least some prokaryotic single-strand annealing proteins (SSAPs) are related to Rad52 have been discussed for more than two decades. Two recent cryo-EM structures, now put the issue beyond doubt.
@article{901e3f89aab84244a9b9c1a17b6efd57,
abstract = {Rad52 is a highly conserved eukaryotic protein that can mediate the annealing of complementary DNA strands to initiate homologous recombination for the repair of double-strand breaks. Suspicions that at least some prokaryotic single-strand annealing proteins (SSAPs) are related to Rad52 have been discussed for more than two decades. Two recent cryo-EM structures, now put the issue beyond doubt.},
added-at = {2024-11-28T16:27:18.000+0100},
author = {Al-Fatlawi, Ali and Schroeder, Michael and Stewart, {A Francis}},
biburl = {https://puma.scadsai.uni-leipzig.de/bibtex/22b602c0cd620e34a22c4039ee381906c/scadsfct},
day = 23,
doi = {10.1038/s42003-023-04476-z},
interhash = {109730739f5c570eb25a9e4af540c636},
intrahash = {2b602c0cd620e34a22c4039ee381906c},
issn = {2399-3642},
journal = {Communications biology},
keywords = {topic_lifescience DNA FIS_scads Homologous Protein/genetics Rad52 Recombination Recombination, Repair and},
language = {English},
month = jan,
note = {Funding Information: We gratefully acknowledge support from ZIH of TU Dresden and the BMBF Project scads.ai.},
number = 1,
publisher = {Springer Nature},
timestamp = {2024-11-28T17:41:30.000+0100},
title = {The Rad52 SSAP superfamily and new insight into homologous recombination},
volume = 6,
year = 2023
}
