Publications

Bernhard Vogginger, Amirhossein Rostami, Vaibhav Jain, Sirine Arfa, Andreas Hantsch, David Kappel, Michael Schäfer, Ulrike Faltings, Hector A. Gonzalez, Chen Liu, and Christian Mayr. Neuromorphic hardware for sustainable AI data centers. Zenodo, 2024. [PUMA: area_responsibleai topic_lifescience] URL

Merlin Lange, Alejandro Granados, Shruthi VijayKumar, Jordão Bragantini, Sarah Ancheta, Yang-Joon Kim, Sreejith Santhosh, Michael Borja, Hirofumi Kobayashi, Erin McGeever, Robert Haase, and others. A multimodal zebrafish developmental atlas reveals the state-transition dynamics of late-vertebrate pluripotent axial progenitors. Cell, (187)23:6742--6759, Elsevier, 2024. [PUMA: topic_lifescience]

Lena Maier-Hein, Annika Reinke, Patrick Godau, Minu D Tizabi, Florian Buettner, Evangelia Christodoulou, Ben Glocker, Fabian Isensee, Jens Kleesiek, Michal Kozubek, Robert Haase, and others. Metrics reloaded: recommendations for image analysis validation. Nature methods, (21)2:195--212, Nature Publishing Group US New York, 2024. [PUMA: topic_lifescience]

Luke Sorensen, Adam Humenick, Sabrina SB Poon, Myat Noe Han, Narges S Mahdavian, Matthew C Rowe, Ryan Hamnett, Estibaliz Gómez-de Mariscal, Peter H Neckel, Ayame Saito, Robert Haase, and others. Gut Analysis Toolbox--automating quantitative analysis of enteric neurons. Journal of Cell Science, (137)20The Company of Biologists, 2024. [PUMA: topic_lifescience]

Merlin Lange, Alejandro Granados, Shruthi VijayKumar, Jordao Bragantini, Sarah Ancheta, Sreejith Santhosh, Michael Borja, Hirofumi Kobayashi, Erin McGeever, Ahmet Can Solak, Robert Haase, and others. Zebrahub--Multimodal zebrafish developmental atlas reveals the State-transition dynamics of late-vertebrate pluripotent axial progenitors. BioRxiv, 2023--03, Cold Spring Harbor Laboratory, 2023. [PUMA: topic_lifescience]

Johannes Soltwedel, Theresa Suckert, Elke Beyreuther, Moritz Schneider, Marc Boucsein, Elisabeth Bodenstein, Sindi Nexhipi, Liane Stolz-Kieslich, Mechthild Krause, Cläre von Neubeck, Robert Haase, and others. Slice2Volume: Fusion of multimodal medical imaging and light microscopy data of irradiation-injured brain tissue in 3D. Radiotherapy and Oncology, (182):109591, Elsevier, 2023. [PUMA: topic_lifescience]

Robert Haase. Towards Transparency and Knowledge Exchange in AI- assisted Data Analysis Code Generation. Zenodo, October 2024. [PUMA: unit_transfer topic_language topic_lifescience] URL

Najia Ahmadi, Quang Vu Nguyen, Martin Sedlmayr, and Markus Wolfien. A comparative patient-level prediction study in OMOP CDM: applicative potential and insights from synthetic data. Scientific reports, (14)1Nature Publishing Group, Jan 27, 2024. [PUMA: Databases, Electronic FIS_scads Factual, Health Humans, Informatics, Learning, Machine Medical Records topic_lifescience]

Suse Seidemann, Florian Salomon, Karl B Hoffmann, Thomas Kurth, Ivo F Sbalzarini, Robert Haase, and Marius Ader. Automated quantification of photoreceptor outer segments in developing and degenerating retinas on microscopy images across scales. FRONTIERS IN MOLECULAR NEUROSCIENCE, (17 (2024))Frontiers Media S.A., May 24, 2024. [PUMA: unit_transfer topic_lifescience FIS_scads imported]

Aryaman Gupta, Ulrik Günther, Pietro Incardona, Guido Reina, Steffen Frey, Stefan Gumhold, and Ivo F. Sbalzarini. Efficient Raycasting of View-Dependent Piecewise Constant Representations of Volumetric Data. Jun 17, 2022. [PUMA: topic_visualcomputing topic_lifescience FIS_scads Human-centered Visualization Visualization, and computing, concepts paradigms, techniques theory,]

Aryaman Gupta, Pietro Incardona, Paul Hunt, Guido Reina, Steffen Frey, Stefan Gumhold, Ulrik Günther, and Ivo F. Sbalzarini. Content-adaptive generation and parallel compositing of volumetric depth images for responsive visualization of large volume data. Jun 29, 2022. [PUMA: topic_visualcomputing topic_lifescience FIS_scads Human-centered Visualization Visualization, and computing, concepts paradigms techniques theory,]

Katja Hoffmann, Igor Nesterow, Yuan Peng, Elisa Henke, Daniela Barnett, Cigdem Klengel, Mirko Gruhl, Martin Bartos, Frank Nüßler, Richard Gebler, Sophia Grummt, Anne Seim, Franziska Bathelt, Ines Reinecke, Markus Wolfien, Jens Weidner, and Martin Sedlmayr. Streamlining intersectoral provision of real-world health data: a service platform for improved clinical research and patient care. Frontiers in medicine, (11):1377209, Frontiers Media S.A., 2024. [PUMA: topic_lifescience FIS_scads imported]

Katja Hoffmann, Yuan Peng, Tobias Schlosser, Gabriel Stolze, Holger Langner, Marcel Susky, Trixy Meyer, Marc Ritter, Danny Kowerko, Vinodh Kakkassery, Markus Wolfien, and Martin Sedlmayr. Towards Standardizing Ophthalmic Data for Seamless Interoperability in Eye Care. Studies in health technology and informatics, (317):139--145, IOS Press, Amsterdam u. a., Aug 30, 2024. [PUMA: topic_lifescience Diseases/therapy, Electronic Eye FIS_scads Germany, Health Humans, Information Interoperability/standards, Learning, Level Machine Ophthalmology Records/standards, Seven/standards,]

Daniel Bühler, Nicole Power Guerra, Luisa Müller, Olaf Wolkenhauer, Martin Düffer, Brigitte Vollmar, Angela Kuhla, and Markus Wolfien. Leptin deficiency-caused behavioral change - A comparative analysis using EthoVision and DeepLabCut. Frontiers in neuroscience, (17)Frontiers Media S.A., Mar 24, 2023. [PUMA: topic_lifescience Behavioral Deep DeepLabCut, EthoVision, FIS_scads Obesity analysis, learning,]

Praveen Vasudevan, Markus Wolfien, Heiko Lemcke, Cajetan Immanuel Lang, Anna Skorska, Ralf Gaebel, Anne-Marie Galow, Dirk Koczan, Tobias Lindner, Wendy Bergmann, Brigitte Mueller-Hilke, Brigitte Vollmar, Bernd Joachim Krause, Olaf Wolkenhauer, Gustav Steinhoff, and Robert David. CCR2 macrophage response determines the functional outcome following cardiomyocyte transplantation. Genome medicine, (15)1BioMed Central, London, Aug 10, 2023. [PUMA: topic_lifescience Animals, C57BL, Cardiac/metabolism, Cell FIS_scads Immunocompromised, Inbred Infarction, Machine Macrophages, Macrophages/metabolism, Mice, Monocytes/metabolism Myocardial Myocytes, Single-cell, infarction, learning, therapy,]

Jan-Niklas Eckardt, Waldemar Hahn, Christoph Röllig, Sebastian Stasik, Uwe Platzbecker, Carsten Müller-Tidow, Hubert Serve, Claudia D Baldus, Christoph Schliemann, Kerstin Schäfer-Eckart, Maher Hanoun, Martin Kaufmann, Andreas Burchert, Christian Thiede, Johannes Schetelig, Martin Sedlmayr, Martin Bornhäuser, Markus Wolfien, and Jan Moritz Middeke. Mimicking clinical trials with synthetic acute myeloid leukemia patients using generative artificial intelligence. npj digital medicine, (7)1Macmillan Publishers Limited, Mar 20, 2024. [PUMA: topic_lifescience FIS_scads imported]

Markus Wolfien, Najia Ahmadi, Kai Fitzer, Sophia Grummt, Kilian-Ludwig Heine, Ian-C Jung, Dagmar Krefting, Andreas Kühn, Yuan Peng, Ines Reinecke, Julia Scheel, Tobias Schmidt, Paul Schmücker, Christina Schüttler, Dagmar Waltemath, Michele Zoch, and Martin Sedlmayr. Ten Topics to Get Started in Medical Informatics Research. Journal of Medical Internet Research, (25)JMIR Publications Inc., Jul 24, 2023. [PUMA: topic_lifescience Algorithms, Clinical Curriculum, Digital FIS_scads Germany, Health Humans, Informatics, Interdisciplinary Medical Research clinical communication, data, digital health health, informatics informatics, interdisciplinary medical research]

Amankeldi A Salybekov, Markus Wolfien, Waldemar Hahn, Sumi Hidaka, and Shuzo Kobayashi. Artificial Intelligence Reporting Guidelines' Adherence in Nephrology for Improved Research and Clinical Outcomes. Biomedicines, (12)3MDPI, Basel, Mar 7, 2024. [PUMA: topic_lifescience FIS_scads imported]

Najia Ahmadi, Michele Zoch, Oya Guengoeze, Carlo Facchinello, Antonia Mondorf, Katharina Stratmann, Khader Musleh, Hans-Peter Erasmus, Jana Tchertov, Richard Gebler, Jannik Schaaf, Lena S Frischen, Azadeh Nasirian, Jiabin Dai, Elisa Henke, Douglas Tremblay, Andrew Srisuwananukorn, Martin Bornhäuser, Christoph Röllig, Jan-Niklas Eckardt, Jan Moritz Middeke, Markus Wolfien, and Martin Sedlmayr. How to customize common data models for rare diseases: an OMOP-based implementation and lessons learned. Orphanet journal of rare diseases, (19)1BioMed Central, London, Aug 14, 2024. [PUMA: topic_lifescience Diseases FIS_scads Humans, Rare]

Najia Ahmadi, Michele Zoch, Patricia Kelbert, Richard Noll, Jannik Schaaf, Markus Wolfien, and Martin Sedlmayr. Methods Used in the Development of Common Data Models for Health Data: Scoping Review. JMIR medical informatics, (11)JMIR Publications Inc., Aug 3, 2023. [PUMA: topic_lifescience FIS_scads imported]

Waldemar Hahn, Najia Ahmadi, Katja Hoffmann, Jan-Niklas Eckardt, Martin Sedlmayr, and Markus Wolfien. Synthetic Data Generation in Hematology - Paving the Way for OMOP and FHIR Integration. Studies in health technology and informatics, (316):1472--1476, IOS Press, Amsterdam u. a., Aug 22, 2024. [PUMA: topic_lifescience Acute, Assessment, Care Electronic FIS_scads Health Hematology, Humans, Information Interoperability, Leukemia, Myeloid, Outcome Records,]

Chaithra Umesh, Manjunath Mahendra, Saptarshi Bej, Olaf Wolkenhauer, and Markus Wolfien. Challenges and applications in generative AI for clinical tabular data in physiology. Pflügers Archiv : European journal of physiology, Springer, Berlin u. a., Oct 17, 2024. [PUMA: topic_lifescience FIS_scads imported]

Ali Al-Fatlawi, Eka Rusadze, Alexander Shmelkin, Negin Malekian, Cigdem Ozen, Christian Pilarsky, and Michael Schroeder. Netrank: network-based approach for biomarker discovery. BMC bioinformatics, (24)1BioMed Central, London, Jul 29, 2023. [PUMA: topic_lifescience Algorithms, Area Biomedical Curve, Disease FIS_scads Gene Humans, Library Progression, Research, Under]

Negin Malekian, Srividhya Sainath, Ali Al-Fatlawi, and Michael Schroeder. Word-based GWAS harnesses the rich potential of genomic data for E. coli quinolone resistance. Frontiers in microbiology, (14):1276332, Frontiers Media S.A., 2023. [PUMA: topic_lifescience FIS_scads imported]

Jirina Zackova Suchanova, Gust Bilcke, Beata Romanowska, Ali Fatlawi, Martin Pippel, Alastair Skeffington, Michael Schroeder, Wim Vyverman, Klaas Vandepoele, Nils Kröger, and Nicole Poulsen. Diatom adhesive trail proteins acquired by horizontal gene transfer from bacteria serve as primers for marine biofilm formation. New Phytologist, (240)2:770--783, Wiley-Blackwell, Oxford u. a., Aug 7, 2023. [PUMA: topic_lifescience Adhesives/metabolism, Bacteria Biofilms, Diatoms/metabolism, FIS_scads Gene Horizontal, Transfer,]

Ali Al-Fatlawi, Martin Menzel, and Michael Schroeder. Is Protein BLAST a thing of the past?. Nature communications, (14)1Nature Publishing Group, Dec 11, 2023. [PUMA: topic_lifescience Databases, FIS_scads Protein, Proteins/genetics]

Ali Al-Fatlawi, Michael Schroeder, and A Francis Stewart. The Rad52 SSAP superfamily and new insight into homologous recombination. Communications biology, (6)1Springer Nature, Jan 23, 2023. [PUMA: topic_lifescience DNA FIS_scads Homologous Protein/genetics Rad52 Recombination Recombination, Repair and]

Abhinav Singh, Quentin Vagne, Frank Jülicher, and Ivo F. Sbalzarini. Spontaneous flow instabilities of active polar fluids in three dimensions. Physical Review Research, (5)2American Physical Society, College Park, April 2023. [PUMA: topic_lifescience FIS_scads imported]

Suryanarayana Maddu, Dominik Sturm, Christian L. Mueller, and Ivo F. Sbalzarini. Inverse Dirichlet weighting enables reliable training of physics informed neural networks. Machine learning: science and technology, (3)1IOP Publishing Ltd., Feb 15, 2022. [PUMA: topic_lifescience ALGORITHM FIS_scads active catastrophic flow forgetting, gradient modeling, multi-objective multi-scale networks, neural physics-informed regularization, training, turbulence,]

Suryanarayana Maddu, Dominik Sturm, Bevan L. Cheeseman, Christian L. Müller, and Ivo F. Sbalzarini. STENCIL-NET for equation-free forecasting from data. Scientific reports, (13)1Nature Publishing Group, December 2023. [PUMA: topic_lifescience FIS_scads imported]

Abhinav Singh, Philipp H. Suhrcke, Pietro Incardona, and Ivo F. Sbalzarini. A numerical solver for active hydrodynamics in three dimensions and its application to active turbulence. Physics of fluids, (35)10American Institute of Physics, Oct 1, 2023. [PUMA: topic_lifescience FIS_scads imported]

Johannes Pahlke, and Ivo F. Sbalzarini. A Unifying Mathematical Definition of Particle Methods. IEEE open journal of the computer society : an open access publication of the IEEE Computer Society, (4):97--108, Institute of Electrical and Electronics Engineers Inc., 2023. [PUMA: topic_lifescience Algorithmics, FIS_scads algorithms, definition, engineering formal mesh-free methods, parallelization, particle simulation software]

Suryanarayana Maddu, Quentin Vagne, and Ivo F. Sbalzarini. Learning deterministic hydrodynamic equations from stochastic active particle dynamics. Jan 21, 2022. [PUMA: topic_lifescience FIS_scads cond-mat.soft, cs.LG, physics.data-an]

Joel Jonsson, Bevan L. Cheeseman, Suryanarayana Maddu, Krzysztof Gonciarz, and Ivo F. Sbalzarini. Parallel Discrete Convolutions on Adaptive Particle Representations of Images. IEEE Transactions on Image Processing, (31):4197--4212, Wiley-IEEE Press, Jan 1, 2022. [PUMA: topic_lifescience Convolution, Data FIS_scads Image Microscopy, Signal processing, reconstruction, resolution resolution, structures,]

Pietro Incardona, Aryaman Gupta, Serhii Yaskovets, and Ivo F. Sbalzarini. A C++ Library for Memory Layout and Performance Portability of Scientific Applications. In Jeremy Singer, Yehia Elkhatib, Dora Blanco Heras, Patrick Diehl, Nick Brown, and Aleksandar Ilic (Eds.), Euro-Par 2022, 109--120, Springer Science and Business Media B.V., Germany, 2023. [PUMA: topic_lifescience C++ FIS_scads GPU, algorithms, generic layout, memory multi-core, performance portability tuples,]

Sarah Perez, Suryanarayana Maddu, Ivo F. Sbalzarini, and Philippe Poncet. Adaptive weighting of Bayesian physics informed neural networks for multitask and multiscale forward and inverse problems. Journal of computational physics, (491)Academic Press Inc., Oct 15, 2023. [PUMA: topic_lifescience Adaptive Artificial Bayesian Carlo, FIS_scads Hamiltonian Intelligence, Monte Multi-objective Quantification Uncertainty learning, networks, neural physics-informed training, weight]

Suryanarayana Maddu, Bevan L. Cheeseman, Ivo F Sbalzarini, and Christian L. Müller. Stability selection enables robust learning of differential equations from limited noisy data. Proceedings of the Royal Society of London : Series A, Mathematical, physical and engineering sciences, (478)2262Royal Society Publishing, June 2022. [PUMA: topic_lifescience FIS_scads PAR differential equations, learning learning, machine proteins, regression, selection, sparse stability statistical theory]

Chiara Molinari, Leonardo Solaini, Francesca Rebuzzi, Gianluca Tedaldi, Davide Angeli, Elisabetta Petracci, Dusan Prascevic, Jan Ewald, Erhard Rahm, Matteo Canale, and others. Genomic events stratifying prognosis of early gastric cancer. Gastric Cancer, 1--12, Springer, 2024. [PUMA: topic_lifescience area_bigdata ep imported]

Fabian Liessmann, Lukas von Bredow, Jens Meiler, and rahm Liebscher, Ines. Targeting adhesion G protein-coupled receptors. Current status and future perspectives. Structure, Elsevier, November 2024. [PUMA: topic_lifescience ADGRG1; ADGRG2; ADGRG3; ADGRG5; ADGRG6; ADGRG7; GPCRs; GPR114; GPR126; GPR128; GPR56; GPR64; GPR97; adhesion area_bigdata discovery; drug ep ligands; molecules; small structure]

Nadja Meumann, Marti Cabanes-Creus, Moritz Ertelt, Renina Gale Navarro, Julie Lucifora, Qinggong Yuan, Karin Nien-Huber, Ahmed Abdelrahman, Xuan-Khang Vu, Liang Zhang, and others. Adeno-associated virus serotype 2 capsid variants for improved liver-directed gene therapy. Hepatology, (77)3:802--815, LWW, 2023. [PUMA: topic_lifescience imported]

Laura M. Chamness, Charles P. Kuntz, Andrew G. McKee, Wesley D. Penn, Christopher M. Hemmerich, Douglas B. Rusch, Hope Woods, Dyotima, Jens Meiler, and Jonathan P. Schlebach. Divergent Pairwise Epistasis in the Context of Unstable Membrane Protein Variants. eLife Sciences Publications, Ltd, December 2023. [PUMA: topic_lifescience imported] URL

Moritz Ertelt, Rocco Moretti, Jens Meiler, and Clara T. Schoeder. Self-supervised machine learning methods for protein design improve sampling, but not the identification of high-fitness variants. Cold Spring Harbor Laboratory, June 2024. [PUMA: topic_lifescience imported] URL

Joseph DeCorte, Benjamin Brown, and Jens Meiler. Interpretable deep-learning pKa prediction for small molecule drugs via atomic sensitivity analysis. American Chemical Society (ACS), June 2024. [PUMA: topic_lifescience imported] URL

Davide Sala, Peter W. Hildebrand, and Jens Meiler. Biasing AlphaFold2 to predict GPCRs and kinases with user-defined functional or structural properties. Frontiers in Molecular Biosciences, (10)Frontiers Media SA, February 2023. [PUMA: topic_lifescience imported] URL

Christopher W. Moth, Jonathan H. Sheehan, Abdullah Al Mamun, R. Michael Sivley, Alican Gulsevin, David Rinker, John A. Capra, and Jens Meiler. VUStruct: a compute pipeline for high throughput and personalized structural biology. Cold Spring Harbor Laboratory, August 2024. [PUMA: topic_lifescience imported] URL

Caleb A. H. Jones, Benjamin P. Brown, Daniel C. Schultz, Julie Engers, Valerie M. Kramlinger, Jens Meiler, and Craig W. Lindsley. Computer-Aided Design and Biological Evaluation of Diazaspirocyclic D4R Antagonists. ACS Chemical Neuroscience, (15)12:2396–2407, American Chemical Society (ACS), June 2024. [PUMA: topic_lifescience imported] URL

Benjamin P. Brown, Richard A. Stein, Jens Meiler, and Hassane Mchaourab. Approximating conformational Boltzmann distributions with AlphaFold2 predictions. Cold Spring Harbor Laboratory, August 2023. [PUMA: topic_lifescience imported] URL

Alican Gulsevin, Bing Han, Jason C. Porta, Hassane S. Mchaourab, Jens Meiler, and Anne K. Kenworthy. Template-free prediction of a new monotopic membrane protein fold and assembly by AlphaFold2. Biophysical Journal, (122)11:2041–2052, Elsevier BV, June 2023. [PUMA: topic_lifescience imported] URL

Alican Gulsevin, Bing Han, Jason C. Porta, Hassane S. Mchaourab, Jens Meiler, and Anne K. Kenworthy. Template-free prediction of a new monotopic membrane protein fold and oligomeric assembly by Alphafold2. Cold Spring Harbor Laboratory, July 2022. [PUMA: topic_lifescience imported] URL

Alican Gulsevin, and Jens Meiler. Benchmarking Peptide Structure Prediction with AlphaFold2. Cold Spring Harbor Laboratory, February 2022. [PUMA: topic_lifescience imported] URL